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Combunex 800 (Ethambutol And Isoniazid)

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$8.83
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Quick Overview

Buy Combunex 800 (Isoniazid 300mg + Ethambutol 800mg) Isoniazid is used in the prevention and treatment of tuberculosis (TB -a serious infection caused by bacteria that affects the lungs and in certain cases other parts of the body). It is always given in combination with other antituberculosis drugs.  Ethambutol is used in the prevention, treatment and recurrence (second time treatment) of tuberculosis (a serious infection caused by bacteria that affects the lungs and in certain cases other parts of the body). It is always given in combination with other antituberculosis drugs. 
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Combunex 800 (Isoniazid 300mg + Ethambutol 800mg)

Uses

Isoniazid is used in the prevention and treatment of tuberculosis (TB -a serious infection caused by bacteria that affects the lungs and in certain cases other parts of the body). It is always given in combination with other antituberculosis drugs.  Ethambutol is used in the prevention, treatment and recurrence (second time treatment) of tuberculosis (a serious infection caused by bacteria that affects the lungs and in certain cases other parts of the body). It is always given in combination with other antituberculosis drugs. 

How it works

Isoniazid belongs to a class of antituberculosis drugs. It suppresses the growth of tuberculosis causing bacteria (Mycobacterium tuberculosis). It interferes with the formation of the outer protective covering (cell wall) of the bacteria by inhibiting the synthesis of a chemical called mycolic acid an essential component of cell wall.
Ethambutol belongs to a class of anti-tuberculosis drugs. It suppresses the growth of tuberculosis causing bacteria (Mycobacterium tuberculosis). Ethambutol enters the growing bacteria and kills the bacteria by inhibiting an important enzyme arabinosyl tranferases involved in the formation of the outer protective covering of the bacteria called cell wall. 

Common side effects

Toxic psychosis, Weakness, High blood sugar levels, Deficiency niacin., Anaemia, Nausea, Liver problems, Discomfort in the upper part of abdomen below the ribs, Abnormal brain function due to drug toxicity, Abnormal blood counts, Vomiting, Breast enlargement in men, Nerve problems in eyes, Constipation, Hypersensitivity reactions, Fits, Memory problems, Dry mouth, Numbness and pain in hands and feet, Severe skin reactions, Swelling of joints, Inflammation of pancreas

Abnormal liver function tests and very rarely liver failure., Numbness and tingling of hands and feet, Itching of skin, Nausea, Inflammation of liver, Vomiting, Skin rashes, Visual disturbances, Pale red raised itchy, High blood levels of uric acid, Loss of appetite, Color blindness, Abdominal pain and diarrhea, Eye pain), Numbness and pain in hands and feet due to nerve damage, Jaundice, Weaknes

Expert advice

  • Do not take isoniazid, if you have severe liver problems or if you have taken isoniazid in the past and it caused liver problems, fever, chills, joint pain, or severe allergic reaction.
  • Contact your doctor immediately, if you experience symptoms such unusual tiredness (fatigue), weakness, feeling of discomfort (malaise), loss of appetite (anorexia), urge to vomit (nausea) or vomiting while taking isoniazid. It indicates that you are progressing towards liver damage.
  • Do consult your doctor before taking isoniazid if you are aged above 35 years. The frequency of isoniazid related inflammation of liver (hepatitis) is higher in individuals older than 35 years of age. The doctor may advice measurement of blood levels of enzyme transferases before starting treatment with isoniazid.
  • Avoid drinking alcohol. It may increase your risk of liver damage while you are taking isoniazid.
  • Do consult your doctor before taking isoniazid, if you are pregnant or planning to become pregnant or are breastfeeding.
  • Isoniazid interacts with many drugs. Please inform your doctor about all the medication you are currently taking to avoid interactions that may reduce effectiveness of any treatment or aggravate side effects.
  • Do not stop taking isoniazid without consulting your doctor.
  • If you forget to take a dose of Isoniazid, take it as soon as you remember. Do not double the dose to make up for the missed dose.

Frequently asked questions

Isoniazid

Q. Is isoniazid an antibiotic?
Isoniazid is an antibiotic used in the prevention and treatment of tuberculosis or TB (a serious infection caused by bacteria that affects the lungs and in certain cases other parts of the body).
 
Q. Is isoniazid safe in pregnancy? Does isoniazid affect pregnancy?
There are no adequate studies of isoniazid in pregnant women. Studies of isoniazid in pregnant in animals have indicated risk to fetus. Isoniazid may be used in pregnant women only if the potential benefit to the mother outweighs the potential risk to fetus. Patients should follow the advice of the doctor regarding its use. Please consult your doctor before taking isoniazid if you are pregnant or planning to become pregnant.
 
Q. Is isoniazid chemotherapy/chemotherapy drug?
Isoniazid is a primary antibiotic used for treatment of tuberculosis. Do not confuse it with chemotherapy or chemo drugs used for the treatment of cancer.
 
Q. Is isoniazid bacteriostatic or bactericidal?
Isoniazid is a bacteriostatic antibiotic. It stops or suppresses growth of tuberculosis causing bacteria by interfering with the formation of protective outer covering (cell wall) which is essential for their growth.
 
Q. Is isoniazid safe?
Yes. Isoniazid is safe if used at prescribed doses for the prescribed duration as advised by your doctor.
 
Q. Is isoniazid a MAOI?
Isoniazid has very weak inhibitory activity on enzymes monoamine oxidases (MAO); however it is not used as a monoamine oxidase inhibitor (MAOI).
 
Q. Is isoniazid a sulfa drug?
No. The chemical structure and mechanism of action of isoniazid is different from sulfa drugs.
 
Q. Is isoniazid an inducer or inhibitor?
Isoniazid is an inhibitor (decreases activity) of an important liver enzyme system that is responsible for the final processing and elimination of several drugs from the body. 
 
Q. Can I take isoniazid with food or milk?
Taking isoniazid with food is known to delay its absorption (process by which the active drug reaches the affected site in the body via blood circulation) thereby, hampering its effectiveness. Multidrug therapy (combination of antituberculosis drugs) for tuberculosis should preferably be taken in the morning before breakfast. 
 
Q. Can I take isoniazid with ibuprofen/Benadryl/Nyquil/Aleve/Mucinex/amoxicillin?
There no known serious drug interactions of isoniazid with ibuprofen, paracetamol (trade name: Tylenol), naproxen (trade name: Aleve), amoxicillin or any active drug present in Nyquil or Mucinex. Please inform your doctor about all the medication you are currently taking to avoid interactions that may reduce effectiveness of any treatment or aggravate side effects.
 
Q. Does isoniazid cause weight loss/weight gain/hair loss/diarrhea/affect menstruation?
Changes in body weight (gain/loss), hair loss, diarrhea or changes in menstruation are not among the known side effects of isoniazid. You may experience few of these side effects while on multi drug (including isoniazid) treatment for tuberculosis. 
 
Q. Does isoniazid cause acne/make you tired/cause constipation?
You may experience unusual tiredness, constipation or acne while on treatment with isoniazid. Please inform your doctor about all the medication you are currently taking to avoid interactions that may reduce effectiveness of any treatment or aggravate side effects.
 
Q. Does isoniazid affect birth control?
Isoniazid has no known interaction with commonly used oral contraceptives (birth control pills). However, multidrug treatment for tuberculosis contains active drug rifampin that decreases the effectiveness of oral contraceptives and hampers birth control.

Ethambutol

Q. Does ethambutol cause blindness?
Optic neuritis (inflammation of nerve fibers that transmit visual information from your eye to the brain) is one of the side effects of ethambutol which causes several forms of eye defect. Although these conditions are reversible upon discontinuation of the drug, rare cases of irreversible blindness have also been reported. Please contact your doctor immediately if you notice any of these symptoms: decreased clearness of vision, loss of vision, disturbed vision due to blind spots, color blindness, visual field defect and eye pain.
 
Q. Does ethambutol induce hyperuricemia/how does ethambutol induce hyperuricemia?
Yes. Increase in blood levels of uric acid is a side effect of ethambutol. It increases the retention of uric acid in the body by decreasing the excretion of urates (uric acid) by the kidneys. 
 
Q. How does ethambutol work in the body?
Ethambutol is an antibiotic effective against tuberculosis causing bacteria. It suppresses the growth of the bacteria by interfering with the formation of the outer protective covering (cell wall) of the bacteria, thereby weakening the bacteria.
 
Q. What is ethambutol toxicity/How does ethambutol cause optic neuritis/how does ethambutol affect vision?
Ethambutol toxicity involves toxic effects on the eyes (optic neuritis/optic neuropathy) which are related to the dose and duration of ethambutol treatment. It causes optic neuritis (inflammation of nerve fibers in the eye) by interfering with important cellular activities (mitochondrial toxicity) in the nerve cells and inducing nerve damage (neuropathy) thereby affecting the transmission of visual information from the eye to brain. The symptoms of ethambutol induced optic neuritis include: decreased clearness of vision, loss of vision, disturbed vision due to blind spots, color blindness, visual field defect and eye pain.
 
Q. What does ethambutol treat?
Ethambutol is an antibiotic effective against tuberculosis causing bacteria. It is used in the prevention, treatment and second time treatment of tuberculosis (a serious infection caused by bacteria that affects the lungs and in certain cases other parts of the body).
 
Q. Is ethambutol bacteriostatic or bactericidal?
Ethambutol is both a bacteriostatic and a bactericidal antibiotic. It suppresses the growth of bacteria (bacteriostatic) by interfering with the formation of the outer protective covering (cell wall) of the bacteria, thereby weakening it and causing cell death in certain cases (bactericidal).
 
Q. Is ethambutol safe in pregnancy?
There are no adequate studies on ethambutol in pregnant women. There are few reports of eye problems in infants born to mothers on multi drug therapy for tuberculosis during pregnancy. Ethambutol should be used during pregnancy only if the potential benefit outweighs the potential risk to the fetus. Please follow the advice of the doctor regarding its use.
 
Q. Is ethambutol hepatotoxic?
Liver toxicities are among the known side effects of ethambutol. Inflammation of liver (hepatitis), abnormal liver function causing yellowing of skin and eyes (jaundice), abnormal liver function tests (blood tests to assess health of liver) and very rarely liver failure have been noted in patients receiving multi drug  (including ethambutol) treatment for tuberculosis. Please contact your doctor before taking ethambutol if you have any liver problems.
 
Q. Is ethambutol toxicity reversible?
In most cases ethambutol toxicities are related to dose (depends upon the quantity of ethambutol you take) and duration of treatment and are reversible upon discontinuation. However, serious irreversible damage to eye and liver has been reported in rare cases.
 
Q. Is ethambutol chemotherapy?
Ethambutol is an antibiotic used in the treatment of tuberculosis. Do not confuse it with chemotherapy or chemo drugs used for the treatment of cancer.
 
Q. Ethambutol is effective against?
Ethambutol is effective against most tuberculosis causing bacteria belonging to Mycobacterium family (M. tuberculosis, M. avium complex, M. kansasii, M. marinum).
Name Combunex 800 (Ethambutol And Isoniazid)
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