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Duovir Tablets (Lamivudine and Zidovudine)

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$45.00
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Quick Overview

Buy Duovir Tablets (Lamivudine 150mg + Zidovudine 300mg), Lamivudine indicated as part of antiretroviral combination therapy for the treatment of Human Immunodeficiency Virus (HIV) infected adults and children and also used in the treatment of Hepatitis B virus infection. Zidovudine is used in combination with other antiretroviral (ART) medicines for the treatment of human immunodeficiency virus (HIV-1) infection. Zidovudine is also indicated for use in HIV-positive pregnant (over 14 weeks) women for prevention of maternal-fetal HIV transmission (passing of infection), and for primary preventive treatment of HIV infection in new-born infants.
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Duovir Tablets (Lamivudine 150mg + Zidovudine 300mg)

Uses

Lamivudine indicated as part of antiretroviral combination therapy for the treatment of Human Immunodeficiency Virus (HIV) infected adults and children and also used in the treatment of Hepatitis B virus infection. Zidovudine is used in combination with other antiretroviral (ART) medicines for the treatment of human immunodeficiency virus (HIV-1) infection. Zidovudine is also indicated for use in HIV-positive pregnant (over 14 weeks) women for prevention of maternal-fetal HIV transmission (passing of infection), and for primary preventive treatment of HIV infection in new-born infants.

How it works

Lamivudine belongs to a class of medication called nucleoside reverse transcriptase inhibitors. It decreases the amount of virus (HIV and hepatitis) in the blood. It also increases the number of infection fighting cells in the body (CD4 cells). It does not cure HIV completely but reduces the chances of getting acquired immunodeficiency syndrome (AIDS) and HIV related infections or cancer.
Zidovudine belongs to a group of medications called nucleoside analogue reverse transcriptase inhibitors (NRTIs), also known as antiretrovirals. Zidovudine does not cure HIV infection; it reduces the amount of viruses in the body by inhibiting the enzyme (viral reverse transcriptase) which is essential for the virus to grow. Further, zidovudine also increases some white blood cells (CD4 cells) of the body that are important in fighting infections.

What is Lamivudine & Zidovudine?

Lamivudine & Zidovudine, also sold under the brands Combivir and Duovir among several other trade names is an antiviral medication consisting of two active ingredients Lamivudine & Zidovudine. This medication belongs to a group of HIV medicines called reverse transcriptase inhibitors that prevent the HIV virus from reproducing in the body.
Lamivudine & Zidovudine is prescribed for the treatment of HIV that causes the disease called acquired immunodeficiency syndrome or AIDS. However, this medication will not cure the body of HIV or AIDS. This medication may also be given for conditions not mentioned here.

Important Information about Lamivudine & Zidovudine

Do not take Lamivudine & Zidovudine anti viral or HIV drug (Combivir, Duovir) if you have a known allergy to it or any medicine that has lamivudine, zidovudine, or emtricitabine. Also, do not take this medication with other medicines that contain lamivudine or zidovudine.
Lactic acidosis has been observed in some people who took Lamivudine & Zidovudine. Initial symptoms of lactic acidosis may deteriorate over time and can prove fatal. Hence you must get medical attention right away on first signs of lactic acidosis such as muscle pain or weakness, numb or cold feeling in the limbs, breathing trouble, stomach pain, or nausea with vomiting.
Lamivudine & Zidovudine can also cause severe or life threatening damage to your liver. Seek medical attention right away if you have any of the following symptoms of liver damage: sever pain in upper stomach which advances to the back, nausea and vomiting, fast heartbeats, itching, loss of appetite, dark urine, clay colored stools, or jaundice.
Lamivudine & Zidovudine can lower the count of white blood cells, the component of blood that helps the body to fight infections. You must take necessary precautions to avoid getting infected such as not being near sick people or avoiding activities that increases the risk of bleeding. Let your doctor know right away if you get any signs of an infection while taking this medication.
Lamivudine is an FDA pregnancy category C drug. It is not known if it can harm an unborn baby if taken while being pregnant. HIV can be transmitted to your baby if you are not treated properly during pregnancy. This medication can pass into breast milk and harm a nursing baby. Do not take this medication if you are breast feeding. Breast feeding is however, not recommended for HIV positive women as they can pass the virus to their baby. You must notify your doctor in advance about your pregnancy, any plans for pregnancy and if you breast feed.
If you have Hepatitis B, you may develop liver symptoms even after stopping Lamivudine & Zidovudine and the symptoms may be seen for months after stopping. You may be required to take regular tests to monitor your liver function.

Before taking Lamivudine & Zidovudine

Before taking Lamivudine & Zidovudine, take care of all precautions mentioned above. Discuss them with your doctor and clear all doubts which you may have about this drug. 
To be sure that Lamivudine & Zidovudine is safe for you, inform your doctor in advance if you have any of the following conditions: kidney disease, bone marrow suppression, or if you have used other HIV drugs in the past.

How should I take Lamivudine & Zidovudine?

Take Lamivudine & Zidovudine HIV/AIDS medication (Combivir, Duovir) strictly according to your doctor’s direction or according to the instructions on the medication label. Do not alter the dosage unless your doctor advises you to do so. Also, do not take this medication after the prescribed period is over. All medications come with a patient leaflet. Refer the instructions in them for detailed information on that particular medication.
You may take Lamivudine & Zidovudine with or without food. HIV/AIDS is usually treated with a combination of drugs. Always take the prescribed drugs as directed by your doctor. Store this medication in a cool and dry place. Always store Lamivudine & Zidovudine in a cool and dry place.

What if I miss a dose?

If you miss a dose of Lamivudine & Zidovudine, take it as soon as you remember. Don’t take the missed dose if the time to take the next dose is almost up. Taking multiple doses near to each other can lead to excess medication in your body which can be harmful.

What if I overdose?

In case of an overdose of Lamivudine & Zidovudine, get emergency medical attention or call the Doctor immediately. Overdose can cause some of the side effects listed below in this guide.

Things and Activities to avoid while taking Lamivudine & Zidovudine

Lamivudine & Zidovudine can lower the count of white blood cells, the component of blood that helps the body to fight infections. You must take necessary precautions to avoid getting infected such as not being near sick people or avoiding activities that increases the risk of bleeding. Let your doctor know right away if you get any signs of an infection while taking this medication.
Lamivudine & Zidovudine will not help your body get rid of HIV/AIDS. It will stop the growth and multiplication of the virus. Chances of spreading the HIV will still remain the same through unprotected sex, infected razors or toothbrush. Hence, avoid these activities and things.

Lamivudine & Zidovudine Side Effects

Some common side effects of Lamivudine & Zidovudine are nausea, headache, vomiting, dizziness, drowsiness, or diarrhea. If any of these effects persist or deteriorate, seek medical attention right away.
Some people may experience a deteriorating of a previous medical condition as their immune system recovers, or develop new conditions due to overactive immune system. Let your doctor known right away if you develop any new condition or any of you existing conditions worsen.
Lactic acidosis has been observed in some people who took Lamivudine & Zidovudine. Initial symptoms of lactic acidosis may deteriorate over time and can prove fatal. Hence you must get medical attention right away on first signs of lactic acidosis such as muscle pain or weakness, numb or cold feeling in the limbs, breathing trouble, stomach pain, or nausea with vomiting.
Lamivudine & Zidovudine can also cause severe or life threatening damage to your liver or pancreas. Seek medical attention right away if you have any of the following symptoms of liver or pancreas damage: sever pain in upper stomach which advances to the back, nausea and vomiting, fast heartbeats, itching, loss of appetite, dark urine, clay colored stools, or jaundice.
The side effects mentioned above are not the only ones that you may experience or witness due to Lamivudine & Zidovudine. If you get any serious side effects due to this medication, contact your doctor right away. 

Lamivudine & Zidovudine Dosing Information

Lamivudine & Zidovudine dosage may depend on a range of factors like age, sex, drug allergies, or seriousness of the condition among several other factors. Your dosage will be determined by your doctor after examining you properly. Remember to follow your doctor’s advice properly for best results.

 

Interaction with other drugs

Inform your doctor if you use any of the following drugs: anti viral drugs such as ganciclovir, anti cancer drugs such as doxorubicin, interferons, or sulfa drugs. These drugs can potentially interact with Lamivudine & Zidovudine. However, these are not all the possible drugs that can interact with Lamivudine & Zidovudine. There may be others. You must inform your doctor in advance if you use any medicines or related products. Never start a new medicine without consulting a doctor first.

Expert advice

  • Consult your doctor if you have diabetes and are using insulin.
  • Patients receiving this therapy are always at a risk for infections and hence should report any such cases to the doctor.
  • Consult your doctor if you take any prescription medication; Inform your doctor if you take other medicine for treatment of HIV or hepatitis B infection, hairy cell leukemia [a type of blood cancer], or antibiotics for infection.
  • Lamivudine may rarely cause a serious side effect like lactic acidosis with symptoms such as pain or weakness of muscle, numbness or feeling cold in arms or legs, stomach pain, nausea, vomiting, lack of breath, aberrant heart rate, dizziness, weak or tired feeling; hence, inform the doctor immediately if you experience any of these symptoms.
  • It is possible to pass on HIV when on this medication and hence it is important to take necessary precautions to prevent HIV from spreading.
  • Inform you doctor if you notice signs of change in the distribution of fat (lipodystrophy), erosion of bones (osteronecrosis), or inflammation of pancreas (pancreatitis).
  • If you are on therapy it is important to use effective non hormonal method of contraception or condom so that a pregnancy can be avoided.
  • Use with caution in pediatric patients with a history of pancreatitis or other significant risk factors for pancreatitis.

Frequently asked questions

Lamivudine

Q. Is lamivudine safe during pregnancy?
Lamivudine can be taken during pregnancy if the benefit outweighs the risk.
 
Q. Is it safe to use lamivudine during breastfeeding?
HIV infected women should not breastfeed for the risk of passing the virus to the baby through the breast milk.
 
Q. Can lamivudine cure hepatitis B?
Lamivudine is used to treat hepatitis B but some patients may be resistant to this drug
 
Q. Can lamivudine be crushed?
Lamivudine cannot be crushed but it can be broken into two parts to give it to children. Please go by the recommendation of the doctor.
 
Q. Can lamivudine cause anemia?
Lamivudine may cause anemia as a side effect in some patients. Kindly consult your doctor in case any side effects are observed.

Zidovudine

Q. Is zidovudine safe during pregnancy?
Zidovudine may harm the baby. Zidovudine should only be given if there is no other alternative drug. Please follow your doctor's advice regarding its use. 
 
Q. Is it safe to use zidovudine during breastfeeding?
Zidovudine is not safe for the baby and should not be used by women who are breastfeeding.
 
Q. Is zidovudine an antibiotic?
No, zidovudine is not an antibiotic; it belongs to a class of drugs called antiretrovirals.
 
Q. Is zidovudine a prodrug?
Yes, zidovudine is a prodrug and must be activated (by phosphorylation in lymphocytes) in the body to exert its antiviral action.
 
Q. Is zidovudine a protease inhibitor?
No, zidovudine is not a protease inhibitor; it is a nucleoside analogue reverse transcriptase inhibitor. 
 
Q. How does zidovudine work? 
Zidovudine belongs to a group of medications called nucleoside analogue reverse transcriptase inhibitors (NRTIs), also known as antiretrovirals. Zidovudine does not cure HIV infection; it reduces the amount of viruses in the body by inhibiting the chemical (viral reverse transcriptase) which is essential for the virus to grow. Further, zidovudine also increases some white blood cells (CD4 cells) of the body that are important in fighting infections.  
 
Q. Does zidovudine cross placenta?
Zidovudine crosses placenta and thereby reducing the HIV transmission from the mother to the fetus.
 
Q. What is zidovudine used for? What does it prevent?
Zidovudine is used in combination with other antiretroviral medicines for the treatment of human immunodeficiency virus (HIV) infection. Zidovudine is also indicated for use in HIV-positive pregnant (over 14 weeks) women for prevention of maternal-fetal HIV transmission (passing of infection), and for primary preventive treatment of HIV infection in new-born infants.
 
Q. How is zidovudine administered?
Zidovudine can be administered as tablets, syrups and suspension in combination with other antiretroviral medications. 
 
Q. Does zidovudine cause muscle pain?
Yes, muscle pain is a known adverse effect of use zidovudine.
 
Q. Does zidovudine cause lipodystrophy?
There are no known effects of zidovudine on lipid distribution and it is not known to cause lipodystrophy.
 
Q. How does zidovudine cause anemia?
Zidovudine is known to cause bone marrow depression and thereby cause anemia (reduction in red blood cell count).
 
Q. How much does zidovudine cost?
The price of zidovudine may vary depending upon the brand prescribed to you. 
Please read the instruction on the package for the correct price of the product.


Name Duovir Tablets (Lamivudine and Zidovudine)
Equivalent Brand Combivir
Strength 150 mg & 300 mg
Generic Name Lamivudine & Zidovudine
PharmaceuticalForm Tablets
Manufacturer Cipla Ltd

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