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  • Xovir – Oral Suspension (70ml)

    Indications: For the treatment of viral infections due to herpes simplex virus (type I & II) and varicella zoster virus (herpes zoster & chickenpox). For the treatment of herpes simplex virus infections of the skin and mucous membranes including initial and recurrent genital herpes. For the prophylaxis of herpes simplex infections in immunocompromised patients.

    Pharmacology: Acyclovir exerts its antiviral effect on herpes simplex viruses (HSV) and varicella-zoster virus by interfering with DNA synthesis and inhibiting viral replication. The exact mechanisms of action against other susceptible viruses have not fully elucidated. In vitro studies with herpes simplex viruses indicate that acyclovir triphosphate is the pharmacologically active form of the drug; the triphosphate functions as both a substrate for and preferential inhibitor of viral DNA polymerase.

    Absorption of Acyclovir from the GI tract is variable and incomplete. It is estimated that 15-30% of an oral dose of the drug is absorbed . Acyclovir is widely distributed into body tissues and fluids including the brain, kidney, saliva, lung, liver, muscle, spleen, uterus, vaginal mucosa and secretions, CSF, and herpetic vesicular fluid. The drug is also distributed into semen, achieving concentrations about 1.4 and 4 times those in plasma during chronic oral therapy at dosages of 400 mg and 1 g daily, respectively.

    Plasma concentrations of Acyclovir appear to decline in a biphasic manner. In adults with normal renal function, the half-life of acyclovir in the initial phase averages 0.34 hours and the half-life in the terminal phase averages 2.1-3.5 hours.

    Dosage & Administration:

    Oral suspension: Children: HSV infections in children over 2 years should be given adult doses and children below 2 years should be given half of the adult dose.
    Interaction
    Concomitant administration of probenecid and acyclovir has reportedly increased the mean plasma half-life and decreased urinary excretion and renal clearance of acyclovir. Amphotericin B has been shown to potentiate the antiviral effect of acyclovir against pseudorabies virus in vitro when both drugs are added to the culture medium. Ketoconazole and acyclovir have shown dose-dependent, synergistic, antiviral activity against herpes simplex virus types 1 and 2 (HSV-1 and HSV-2) in in-vitro replication studies.

    Contraindications: Acyclovir is contraindicated in patients known to be hypersensitive to acyclovir. For the patients with severe renal impairment, a reduction of the doses is recommended.

    Therapeutic Class: Antivirals (Systemic Antifungal, Antiviral and Antiprotozoal Agents)
    Generic Name: Acyclovir
  • Clovir – 400 mg

    Indications: For the treatment of viral infections due to herpes simplex virus (type I & II) and varicella zoster virus (herpes zoster & chickenpox). For the treatment of herpes simplex virus infections of the skin and mucous membranes including initial and recurrent genital herpes. For the prophylaxis of herpes simplex infections in immunocompromised patients.

    Pharmacology: Acyclovir exerts its antiviral effect on herpes simplex viruses (HSV) and varicella-zoster virus by interfering with DNA synthesis and inhibiting viral replication. The exact mechanisms of action against other susceptible viruses have not fully elucidated. In vitro studies with herpes simplex viruses indicate that acyclovir triphosphate is the pharmacologically active form of the drug; the triphosphate functions as both a substrate for and preferential inhibitor of viral DNA polymerase.

    Absorption of Acyclovir from the GI tract is variable and incomplete. It is estimated that 15-30% of an oral dose of the drug is absorbed . Acyclovir is widely distributed into body tissues and fluids including the brain, kidney, saliva, lung, liver, muscle, spleen, uterus, vaginal mucosa and secretions, CSF, and herpetic vesicular fluid. The drug is also distributed into semen, achieving concentrations about 1.4 and 4 times those in plasma during chronic oral therapy at dosages of 400 mg and 1 g daily, respectively.

    Therapeutic Class: Antivirals (Systemic Antifungal, Antiviral and Antiprotozoal Agents)
    Generic Name: Acyclovir

    Clovir – 400 mg

    ৳ 21.90
  • Clovir – 200 mg

    Indications: For the treatment of viral infections due to herpes simplex virus (type I & II) and varicella zoster virus (herpes zoster & chickenpox). For the treatment of herpes simplex virus infections of the skin and mucous membranes including initial and recurrent genital herpes. For the prophylaxis of herpes simplex infections in immunocompromised patients.

    Pharmacology: Acyclovir exerts its antiviral effect on herpes simplex viruses (HSV) and varicella-zoster virus by interfering with DNA synthesis and inhibiting viral replication. The exact mechanisms of action against other susceptible viruses have not fully elucidated. In vitro studies with herpes simplex viruses indicate that acyclovir triphosphate is the pharmacologically active form of the drug; the triphosphate functions as both a substrate for and preferential inhibitor of viral DNA polymerase.

    Absorption of Acyclovir from the GI tract is variable and incomplete. It is estimated that 15-30% of an oral dose of the drug is absorbed . Acyclovir is widely distributed into body tissues and fluids including the brain, kidney, saliva, lung, liver, muscle, spleen, uterus, vaginal mucosa and secretions, CSF, and herpetic vesicular fluid. The drug is also distributed into semen, achieving concentrations about 1.4 and 4 times those in plasma during chronic oral therapy at dosages of 400 mg and 1 g daily, respectively.

    Therapeutic Class: Antivirals (Systemic Antifungal, Antiviral and Antiprotozoal Agents)
    Generic Name: Acyclovir

    Clovir – 200 mg

    ৳ 13.94
  • Viroxi – 200 mg

    Indications: For the treatment of viral infections due to herpes simplex virus (type I & II) and varicella zoster virus (herpes zoster & chickenpox). For the treatment of herpes simplex virus infections of the skin and mucous membranes including initial and recurrent genital herpes. For the prophylaxis of herpes simplex infections in immunocompromised patients.

    Pharmacology: Acyclovir exerts its antiviral effect on herpes simplex viruses (HSV) and varicella-zoster virus by interfering with DNA synthesis and inhibiting viral replication. The exact mechanisms of action against other susceptible viruses have not fully elucidated. In vitro studies with herpes simplex viruses indicate that acyclovir triphosphate is the pharmacologically active form of the drug; the triphosphate functions as both a substrate for and preferential inhibitor of viral DNA polymerase.

    Absorption of Acyclovir from the GI tract is variable and incomplete. It is estimated that 15-30% of an oral dose of the drug is absorbed . Acyclovir is widely distributed into body tissues and fluids including the brain, kidney, saliva, lung, liver, muscle, spleen, uterus, vaginal mucosa and secretions, CSF, and herpetic vesicular fluid. The drug is also distributed into semen, achieving concentrations about 1.4 and 4 times those in plasma during chronic oral therapy at dosages of 400 mg and 1 g daily, respectively.

    Plasma concentrations of Acyclovir appear to decline in a biphasic manner. In adults with normal renal function, the half-life of acyclovir in the initial phase averages 0.34 hours and the half-life in the terminal phase averages 2.1-3.5 hours.

    Dosage & Administration: Tablet: For the treatment of initial and recurrent episodes of herpes simplex infections in adults, 200 mg Acyclovir tablet should be taken 5 times daily (at 4 hours intervals omitting the night-time dose). Treatment should continue for 5 days and may be extended for up to 10 days in severe initial infections. For suppression of herpes simplex infections in adults, treatment with Acyclovir tablet should be continued at a dose of 200 mg 4 times daily or 400 mg twice daily for up to 1 year. If the patient remains recurrence free for up to 2-3 months, this dose can be reduced to 200 mg 3 times daily. After 1 year, treatment should be stopped to reassess patient’s clinical status. For prophylaxis of herpes simplex infections in immune-compromised patients, 200 mg Acyclovir tablet should be taken four times daily at 6 hourly intervals for 7 days. In severely immune-compromised patients (e.g. after bone marrow transplantation) or in patients with impaired absorption from the gut, the dose can be doubled. For treatment of herpes zoster infections in adults, 800 mg Acyclovir tablet should be taken 5 times daily (at 4 hourly intervals) for 7 days.

    Interaction: Concomitant administration of probenecid and acyclovir has reportedly increased the mean plasma half-life and decreased urinary excretion and renal clearance of acyclovir. Amphotericin B has been shown to potentiate the antiviral effect of acyclovir against pseudorabies virus in vitro when both drugs are added to the culture medium. Ketoconazole and acyclovir have shown dose-dependent, synergistic, antiviral activity against herpes simplex virus types 1 and 2 (HSV-1 and HSV-2) in in-vitro replication studies.

    Contraindications: Acyclovir is contraindicated in patients known to be hypersensitive to acyclovir. For the patients with severe renal impairment, a reduction of the doses is recommended.

    Therapeutic Class: Antivirals (Systemic Antifungal, Antiviral and Antiprotozoal Agents)
    Generic Name: Acyclovir
    Manufacturer: Eskayef Bangladesh Ltd

    Viroxi – 200 mg

    ৳ 14.00
  • Simplovir – 400 mg

    Indications: For the treatment of viral infections due to herpes simplex virus (type I & II) and varicella zoster virus (herpes zoster & chickenpox). For the treatment of herpes simplex virus infections of the skin and mucous membranes including initial and recurrent genital herpes. For the prophylaxis of herpes simplex infections in immunocompromised patients.

    Pharmacology: Acyclovir exerts its antiviral effect on herpes simplex viruses (HSV) and varicella-zoster virus by interfering with DNA synthesis and inhibiting viral replication. The exact mechanisms of action against other susceptible viruses have not fully elucidated. In vitro studies with herpes simplex viruses indicate that acyclovir triphosphate is the pharmacologically active form of the drug; the triphosphate functions as both a substrate for and preferential inhibitor of viral DNA polymerase.

    Therapeutic Class: Antivirals (Systemic Antifungal, Antiviral and Antiprotozoal Agents)
    Generic Name: Acyclovir
    Manufacturer: Incepta Pharmaceuticals Ltd.
  • Simplovir – 200 mg

    Indications: For the treatment of viral infections due to herpes simplex virus (type I & II) and varicella zoster virus (herpes zoster & chickenpox). For the treatment of herpes simplex virus infections of the skin and mucous membranes including initial and recurrent genital herpes. For the prophylaxis of herpes simplex infections in immunocompromised patients.

    Pharmacology: Acyclovir exerts its antiviral effect on herpes simplex viruses (HSV) and varicella-zoster virus by interfering with DNA synthesis and inhibiting viral replication. The exact mechanisms of action against other susceptible viruses have not fully elucidated. In vitro studies with herpes simplex viruses indicate that acyclovir triphosphate is the pharmacologically active form of the drug; the triphosphate functions as both a substrate for and preferential inhibitor of viral DNA polymerase.

    Therapeutic Class: Antivirals (Systemic Antifungal, Antiviral and Antiprotozoal Agents)
    Generic Name: Acyclovir
    Manufacturer: Incepta Pharmaceuticals Ltd.
  • Acerux Oral Suspension – 70 ml

    Indications: For the treatment of viral infections due to herpes simplex virus (type I & II) and varicella zoster virus (herpes zoster & chickenpox). For the treatment of herpes simplex virus infections of the skin and mucous membranes including initial and recurrent genital herpes. For the prophylaxis of herpes simplex infections in immunocompromised patients.

    Pharmacology: Acyclovir exerts its antiviral effect on herpes simplex viruses (HSV) and varicella-zoster virus by interfering with DNA synthesis and inhibiting viral replication. The exact mechanisms of action against other susceptible viruses have not fully elucidated. In vitro studies with herpes simplex viruses indicate that acyclovir triphosphate is the pharmacologically active form of the drug; the triphosphate functions as both a substrate for and preferential inhibitor of viral DNA polymerase.

    Therapeutic Class: Antivirals (Systemic Antifungal, Antiviral and Antiprotozoal Agents)
    Generic Name: Acyclovir
    Manufacturer: Opsonin Pharma Ltd
  • Acerux® – 400 mg

    Description:
    Acyclovir is a synthetic purine derivative.
    Indications:
    Chicken pox, Cold sore, Shingles, Herpes encephalitis & Genital Herpes.
    Mode of Action:
    Viral (HSV-1, HSV-2 and VZV) thymidine kinase converts Acyclovir to the Acyclovir monophosphate, which is then convefted to the diphosphate by cellular guanylate kinase and finally to the triphosphate. Acyclovir triphosphate competitively inhibits viral DNA polymerase, Once incorporated, Acyclovir triphosphate inhibits DNA synthesis by acting as a chain terminator.
    Therapeutic Class: Antivirals (Systemic Antifungal, Antiviral and Antiprotozoal Agents)
    Generic Name: Acyclovir
    Manufacturer: Opsonin Pharma Ltd
  • Acerux® – 200 mg

    Description:
    Acyclovir is a synthetic purine derivative.
    Indications:
    Chicken pox, Cold sore, Shingles, Herpes encephalitis & Genital Herpes.
    Mode of Action:
    Viral (HSV-1, HSV-2 and VZV) thymidine kinase converts Acyclovir to the Acyclovir monophosphate, which is then convefted to the diphosphate by cellular guanylate kinase and finally to the triphosphate. Acyclovir triphosphate competitively inhibits viral DNA polymerase, Once incorporated, Acyclovir triphosphate inhibits DNA synthesis by acting as a chain terminator.
    Therapeutic Class: Antivirals (Systemic Antifungal, Antiviral and Antiprotozoal Agents)
    Generic Name: Acyclovir
    Manufacturer: Opsonin Pharma Ltd
  • Novirax Tablet- 400 mg

    Indications : Novirax tablet is indicated for the treatment of viral infections due to herpes simplex virus (type I & II) and vericella zoster virus (herpes zoster & chicken pox). It is indicated for the treatment of herpes simplex virus infections of the skin and mucous membranes including initial and recurrent genital herpes. Novirax tablet is also indicated for the prophylaxis of herpes simplex infections in immunocompromised patients.

    Dosage & administration :Oral : Herpes simplex initial therapy :200mg 5 times daily for 10 days. Herpes simplex chronic suppressive therapy : 200-400mg 2 to 4 times daily for 12 months. Herpes Zoster : 800mg 5 times at 4 hrs intervals for 7-10 days. Varicela Zoster : 20mg/kg (not more than 800mg) 4 times daily for 5 days.

    Children : Under 2 years should be given half of these doses. Elderly : Dosage may also be reduced as required. Or, as directed by the physician.

    Use in pregnancy and lactation : There are no adequate and well controlled studies in pregnant women. Novirax should be administered to a nursing mother with caution and only when indicated. Novirax should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

  • Novirax Tablet- 200 mg

    Indications : Novirax tablet is indicated for the treatment of viral infections due to herpes simplex virus (type I & II) and vericella zoster virus (herpes zoster & chicken pox). It is indicated for the treatment of herpes simplex virus infections of the skin and mucous membranes including initial and recurrent genital herpes. Novirax tablet is also indicated for the prophylaxis of herpes simplex infections in immunocompromised patients.

    Dosage & administration :Oral : Herpes simplex initial therapy :200mg 5 times daily for 10 days. Herpes simplex chronic suppressive therapy : 200-400mg 2 to 4 times daily for 12 months. Herpes Zoster : 800mg 5 times at 4 hrs intervals for 7-10 days. Varicela Zoster : 20mg/kg (not more than 800mg) 4 times daily for 5 days.

    Children : Under 2 years should be given half of these doses. Elderly : Dosage may also be reduced as required. Or, as directed by the physician.

    Use in pregnancy and lactation : There are no adequate and well controlled studies in pregnant women. Novirax should be administered to a nursing mother with caution and only when indicated. Novirax should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

  • Novirax – Cream (5 gm)

    Acyclovir BP

    Composition : Acyclovir BP 5%.

    Indication : Novirax cream is indicated for the treatment of Herpes simplex virus infections of the skin and mucous membranes including initial and recurrent genital herpes. Novirax cream is also indicated for the prophylaxis of herpes simplex infections in immunocompro-mised patients.

    Dosage and administration : Novirax cream should be used every 4 hours for 5 days in the affected area. If after 5 days, healing is not complete then treatment may be continued for a further 5 days. Or as directed by the physician.

    Packing : Novirax cream : 5gm in a tubes

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