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  • Xovir – Oral Suspension (70ml)

    Indications: For the treatment of viral infections due to herpes simplex virus (type I & II) and varicella zoster virus (herpes zoster & chickenpox). For the treatment of herpes simplex virus infections of the skin and mucous membranes including initial and recurrent genital herpes. For the prophylaxis of herpes simplex infections in immunocompromised patients.

    Pharmacology: Acyclovir exerts its antiviral effect on herpes simplex viruses (HSV) and varicella-zoster virus by interfering with DNA synthesis and inhibiting viral replication. The exact mechanisms of action against other susceptible viruses have not fully elucidated. In vitro studies with herpes simplex viruses indicate that acyclovir triphosphate is the pharmacologically active form of the drug; the triphosphate functions as both a substrate for and preferential inhibitor of viral DNA polymerase.

    Absorption of Acyclovir from the GI tract is variable and incomplete. It is estimated that 15-30% of an oral dose of the drug is absorbed . Acyclovir is widely distributed into body tissues and fluids including the brain, kidney, saliva, lung, liver, muscle, spleen, uterus, vaginal mucosa and secretions, CSF, and herpetic vesicular fluid. The drug is also distributed into semen, achieving concentrations about 1.4 and 4 times those in plasma during chronic oral therapy at dosages of 400 mg and 1 g daily, respectively.

    Plasma concentrations of Acyclovir appear to decline in a biphasic manner. In adults with normal renal function, the half-life of acyclovir in the initial phase averages 0.34 hours and the half-life in the terminal phase averages 2.1-3.5 hours.

    Dosage & Administration:

    Oral suspension: Children: HSV infections in children over 2 years should be given adult doses and children below 2 years should be given half of the adult dose.
    Interaction
    Concomitant administration of probenecid and acyclovir has reportedly increased the mean plasma half-life and decreased urinary excretion and renal clearance of acyclovir. Amphotericin B has been shown to potentiate the antiviral effect of acyclovir against pseudorabies virus in vitro when both drugs are added to the culture medium. Ketoconazole and acyclovir have shown dose-dependent, synergistic, antiviral activity against herpes simplex virus types 1 and 2 (HSV-1 and HSV-2) in in-vitro replication studies.

    Contraindications: Acyclovir is contraindicated in patients known to be hypersensitive to acyclovir. For the patients with severe renal impairment, a reduction of the doses is recommended.

    Therapeutic Class: Antivirals (Systemic Antifungal, Antiviral and Antiprotozoal Agents)
    Generic Name: Acyclovir
  • Acerux Oral Suspension – 70 ml

    Indications: For the treatment of viral infections due to herpes simplex virus (type I & II) and varicella zoster virus (herpes zoster & chickenpox). For the treatment of herpes simplex virus infections of the skin and mucous membranes including initial and recurrent genital herpes. For the prophylaxis of herpes simplex infections in immunocompromised patients.

    Pharmacology: Acyclovir exerts its antiviral effect on herpes simplex viruses (HSV) and varicella-zoster virus by interfering with DNA synthesis and inhibiting viral replication. The exact mechanisms of action against other susceptible viruses have not fully elucidated. In vitro studies with herpes simplex viruses indicate that acyclovir triphosphate is the pharmacologically active form of the drug; the triphosphate functions as both a substrate for and preferential inhibitor of viral DNA polymerase.

    Therapeutic Class: Antivirals (Systemic Antifungal, Antiviral and Antiprotozoal Agents)
    Generic Name: Acyclovir
    Manufacturer: Opsonin Pharma Ltd
  • Virux® | Oral Suspension (70 ml)

    Indication:
    For the treatment of viral infections due to herpes simplex virus (type I & II) and varicella zoster virus (herpes zoster & chickenpox).
    For the treatment of herpes simplex virus infections of the skin and mucous membranes including initial and recurrent genital herpes.
    For the prophylaxis of herpes simplex infections in immunocompromised patients.

    Dosage & Administration:
    Treatment of initial herpes simplex: 200 mg 5 times daily usually for 5 days. For immunocompromised patients 400 mg 5 times daily for 5 days (longer if new lesions appear during treatment or if healing incomplete; increase dose to 800 mg 5 times daily for genital herpes in immuno-compromised) or as directed by the registered physician.
    Children under 2 years: half of the adults dose.
    Children over 2 years: Adult dose.
    Prevention of recurrence of herpes simplex: 200 mg 4 times daily or 400 mg twice daily possibly reduced to 200 mg 2 or 3 times daily and interrupted every 6-12 months.
    Children under 2 years: Half of the adult dose.
    Children over 2 years: Adult dose.
    Prophylactic treatment of herpes simplex in the immunocompromised: 200 to 400 mg 4 times daily.
    Children under 2 years: Half of the adult dose.
    Children over 2 years: Adult dose.
    Treatment of vericella (chicken pox): Adult and children over 40 kg – 800 mg 4 times daily for 5 days.
    Children below 40 kg: 20 mg / kg (maximum 800 mg) per dose orally 4 times daily (80 mg / kg/day) for 5 days.
    Or, Children under 2 years : 200 mg 4 times daily
    Children 2-5 years : 400 mg 4 times daily
    Children Over 6 years : 800 mg 4 times daily
    Treatment of herpes zoster (Shingles): 800 mg 5 times daily for 7 days.
    Treatment of initial rectal (Proctitis) herpes infections: An oral Aciclovir dosage of 400 mg 5 times daily for 10 days or until clinical resolution occurs has been recommended.
    Cream : Virux® cream should be applied to lesions or impending lesions 5 times daily (at 4 hourly intervals omitting the night-time dose). Treatment should continue for 5 days. If healing does not occur, treatment may be extended for up to 10 days.
    Children :
    HSV infections in children over 2 years should be given adult doses and children below 2 years should be given half of the adult dose.

    Preparation:
    Virux® tablet : Box containing 3 x 10 tablets in blister pack.

     

     

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