Grafil – IV/SC Injection 300 mcg/0.5 ml – 0.5ml syringe/pcs

৳  2,700.00

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Generic Name: Filgrastim
Therapeutic class: Granulocyte Colony Stimulating factor (GCSF) (Anticancer)
Manufacturer: Drug International Ltd

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Filgrastim is indicated to those:

  • Cancer patients receiving myelosuppressive chemotherapy
  • Patients with Acute Myeloid Leukemia receiving induction or consolidation chemotherapy
  • Cancer patients receiving bone marrow transplant
  • Patients with severe neutropenia
  • Peripheral blood progenitor cell collection and therapy

Dosage & Administration


Chemotherapy-induced neutropenia: 5 mcg/kg daily as a single daily SC inj, as a continuous IV or SC infusion, or as a daily IV infusion over 15-30 minutes, starting not

Bone marrow transplantation: 10 mcg/kg daily by IV infusion over 30 min or 4 hr or continuous IV or SC infusion over 24 hr. Adjust according to response.


Mobilisation of peripheral blood progenitor cells for autologous peripheral blood stem cell transplantation: 10 mcg/kg daily, as a single inj or by continuous infusion, for 4-7 days until the last leucapheresis procedure. If it is given after myelosuppressive chemotherapy: 5 mcg/kg daily by inj; given from the 1st day after chemotherapy completion until expected neutrophil nadir is passed and neutrophil count has returned to normal range, so that leucapheresis can be performed.

Congenital neutropenia: 12 mcg/kg daily in single or divided doses. Adjust according to response. In patients with cyclic or idiopathic neutropenia: 5 mcg/kg daily in single or divided doses. Adjust according to response.

HIV infection and persistent neutropenia: Initially, 1 mcg/kg daily. Dose may be increased to 4 mcg/kg daily until normal neutrophil count is achieved. Maintenance: 300 mcg daily. Max: 4 mcg/kg daily.

Side Effects

Musculoskeletal pain, bone pain, hypersensitivity reactions, splenic enlargement, hepatomegaly, thrombocytopaenia, anaemia, epistaxis, headache, nausea, vomiting, diarrhoea, urinary abnormalities (dysuria, proteinuria, haematuria), osteoporosis, exacerbation of rheumatoid arthritis, transient decrease in blood glucose, raised uric acid, cutaneous vasculitis, transient hypotension.

Pregnancy & Lactation

Category C: Either studies in animals have revealed adverse effects on the foetus (teratogenic or embryocidal or other) and there are no controlled studies in women or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the foetus.

Precautions & Warnings

Filgrastim should not be administered within 24 hours before and after chemotherapy  The possibility of Filgrastim acting as a growth factor for any tumor type cannot be excluded. To avoid adverse effects of excessive neutrophils complete blood count is recommended twice per week during treatment. Filgrastim is given by subcutaneous or intravenous infusion as required

Use in Special Populations

Pediatric precautions: Filgrastim has been used in children 3 months to 18 years of age without unusual adverse effect. However, safety and efficacy of the drug in neonates or patients with autoimmune neutropenia of infancy have not been established.

Overdose Effects

The possibility of Filgrastim acting as a growth factor for any tumor type and adverse effects of excessive neutrophils may occur in overdose of Filgrastim.

Therapeutic Class

Haematopoietic Agents


Dilution of Filgrastim conc less than 5 mcg/ml is not recommended at any time. Filgrastim may be diluted in 5% dextrose as required

Storage Conditions

Refrigerate at 2-8° C. Do not freeze.

* চিকিৎসকের পরামর্শ মোতাবেক ঔষধ সেবন করুন


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Grafil  - IV-SC Injection 300 mcg-0.5 ml - 0.5ml syringe ( Drug )

Grafil - IV/SC Injection 300 mcg/0.5 ml - 0.5ml syringe/pcs

৳  2,700.00

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