Klarix – Powder for Suspension (125 mg/5 ml – 60 ml bottle)/pcs

৳  340.00

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Generic Name: Clarithromycin
Therapeutic class: Macrolides (Other Antibacterials)
Manufacturer: Incepta Pharmaceuticals Ltd

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Indications

Clarithromycin is indicated in-

  • Streptococcal pharyngitis
  • Sinusitis
  • Infective exacerbations of chronic bronchitis
  • Community-acquired pneumonia
  • Atypical pneumonia
  • Skin and soft tissue infection
  • Adjunct in the treatment of duodenal ulcers by eradication of H.pylori.

Dosage & Administration

Adults:

  • Pharyngitis / Tonsillitis 250 mg every 12 hours for 10 days.
  • Acute maxillary sinusitis 500 mg every 12 hours for 14 days.
  • Chronic bronchitis 250-500 mg every 12 hours for 7-14 days.
  • Pneumonia 250 mg every 12 hours for 7-14 days.
  • Uncomplicated skin & skin structure infections 250 mg every 12 hours for 7-14 days.
  • Community-acquired upper and lower respiratory tract infections 250-500 mg every 12 hours for 5-14 days.

Children:

  • Bodyweight under 8 kg: 7.5 mg/kg twice daily.
  • Bodyweight of 8-11 kg (1-2 years): 2.5 ml (Half teaspoonful) twice daily.
  • Bodyweight of 12-19 kg (3-6 years): 5 ml (One teaspoonful) twice daily.
  • Bodyweight of 20-29 kg (7-9 years): 7.5 ml (One & half teaspoonfuls) twice daily.
  • Bodyweight of 30-40 kg (10-12 years): 10 ml (Two teaspoonfuls) twice daily.

Side Effects

Clarithromycin is generally well tolerated. Side effects include nausea, vomiting, diarrhoea and abdominal pain. Stomatitis and glossitis have also been reported. Other side effects include headache, allergic reactions ranging from urticaria and mild skin reactions to anaphylaxis. Taste perversion may occur. There have been reports of transient central nervous system side effects including anxiety, dizziness, insomnia and hallucination.

Pregnancy & Lactation

The drug may be used in neonates and children in appropriate doses. Breast milk from mothers receiving Clarithromycin should not be given to infants until treatment is completed. There is as yet little experience in the treatment of pregnant patients and Clarithromycin is not recommended.

Precautions & Warnings

Clarithromycin is principally excreted by the liver and kidney. Caution should be taken in administering this antibiotic to patients with impaired hepatic and renal function. Prolonged or repeated use of Clarithromycin may result in an overgrowth of non-susceptible bacteria or fungi. If superinfection occurs, Clarithromycin should be discontinued and appropriate therapy should be instituted.

Overdose Effects

Reports indicate that the ingestion of large amounts of clarithromycin can be expected to produce gastro-intestinal symptoms. One patient who had a history of bipolar disorder ingested 8 grams of clarithromycin and showed altered mental status, paranoid behaviour, hypokalemia and hypoxemia. Adverse reactions accompanying overdosage should be treated by the prompt elimination of unabsorbed drug and supportive measures. As with other macrolides, clarithromycin serum levels are not expected to be appreciably affected by haemodialysis or peritoneal dialysis.

Storage Conditions

Store in a cool and dry place, protected from light & moisture. The reconstituted suspension must be used within 7 days if kept at room temperature and within 14 days when stored in a refrigerator. Keep out of reach of children.

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Klarix - Powder for Suspension (125 mg/5 ml - 60 ml bottle)/pcs

৳  340.00

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