Perigen – 5 mg Tablet/pcs

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Generic Name: Haloperidol
Therapeutic class: Typical Antipsychotic (CNS Preparations)
Manufacturer: General Pharmaceuticals Ltd

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Indications

In low doses-

  • nervousness, anxiety states and associated psychic disorders as irritability gressiveness, psychic lability and insomnia
  • functional disorders caused by anxiety states such as trembling, thorax oppression, gastrointestinal hypermotility and digestive disorders
  • tics and stuttering
  • nausea and vomiting

In higher doses-

  • psychomotor agitation in mania, dementia, acute and chronic schizophrenia, alcoholism
  • delusions and hallucinations in acute and chronic schizophrenia, acute confusion
  • choreatic movements
  • behavior and character disorders in children
  • tics and stuttering
  • vomiting

Dosage & Administration

Tablet
Initial dose for adults-

  • Moderate symptomatology: 0.5 mg to 3.0 mg 2 to 3 times daily
  • Severe symptomatology: 3.0 mg to 5.0 mg 2 to 3 times daily
  • Elderly patients: 0.5 mg to 4.5 mg 2 to 3 times daily
  • Chronic or Resistant patients: 3.0 mg to 6.0 mg 2 to 3 times daily

Patients who remain severely disturbed or inadequately controlled may require dose adjustment. Daily dose upto 100 mg may be necessary in some cases to achieve optimal response.

Children: A suggested dose for the management of behaviour disorders in disturbed and schizophrenic children is 50 microgram per kg body weight.

Injection (intramuscular or intravenous)
Schizophrenia and other psychosis, mania:

  • Initially 2-10 mg, then every 4-8 hours according to response to total maximum 18 mg daily
  • Severely disturbed patients may require an initial dose of up to 18 mg
  • Elderly (or debilitated) initially half adult dose
  • For children not recommended.

Side Effects

Haloperidol is a safe neuroleptic. Headache, vertigo, insomnia are the more common side effects encountered. Drowsiness, lethargy, stupor, confusion, restlessness, agitation, anxiety, euphoria and exacerbation of psychotic symptoms including hallucinations also may occur. Dry mouth, blurred vision, urinary retention, heartburn, nausea, vomiting, anorexia, diarrhea and hypersalivation have also been reported.

Pregnancy & Lactation

Safety for use in pregnancy and lactation has not been established; do not administer to women of childbearing potential or nursing mothers unless, in the opinion of the physician, the expected benefits of the drug outweigh the potential hazard to the fetus or child. Haloperidol is excreted in breast milk.

Precautions & Warnings

Haloperidol may lower the convulsive threshold and has been reported to trigger seizures in previously controlled known epileptics. When instituting haloperidol therapy in these patients, adequate anticonvulsant medication should be maintained concomitantly. As with other antipsychotic agents, haloperidol should be administered cautiously to patients with severe impairment of liver or kidney function and to patients with known allergies or history of allergies to other neuroleptic drugs. Caution is also advised in patients with pheochromocytoma and conditions predisposing to epilepsy such as alcohol withdrawal and brain damage. Since the drug may have a possible potentiating effect on potent analgesics or hypnotics, caution is recommended when prescribing it to patients who are regularly treated with such drugs.

Overdose Effects

In general, the symptoms of overdosage would be an exaggeration of known pharmacologic effects and adverse reactions, the most prominent of which would be: severe extrapyramidal reactions, hypotension or sedation.The patient would appear comatose with respiratory depression and hypotension which could be severe enough to produce a shock-like state.

Therapeutic Class

Butyrophenone drugs, Drugs used in tremor, tics & related disorder

Storage Conditions

Do not store above 30°C. Keep away from light and out of the reach of children.

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Perigen - 5 mg Tablet ( General )

Perigen - 5 mg Tablet/pcs

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