VIR – 0.50 mg Tablet/pcs

৳  48.14

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Generic Name: Entecavir
Therapeutic class: Antivirals (Systemic Antifungal, Antiviral and Antiprotozoal Agents)
Manufacturer: ACME Laboratories Ltd

Note: চিকিৎসকের পরামর্শ মোতাবেক  ঔষধ সেবন করুন

 

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Indications

Entecavir is indicated for the treatment of chronic hepatitis B virus infection in adults with compensated liver disease, evidence of viral replication and histologically documented active liver inflammation or fibrosis. It is also effective in decompensated cirrhosis.

Dosage & Administration

Administration of Entecavir with food decreases absorption and so it should be taken in an empty stomach (at least 2 hours before or 2 hours after meal).

Adult over 16 years, not previously treated with nucleoside analogues: 0.5 mg once daily.

Adult over 16 years with lamivudine or telbivudine resistant chronic hepatitis B: 1 mg once daily.

Side Effects

The most common side effects are headache, fatigue, dizziness and nausea.

Pregnancy & Lactation

Use in pregnancy: There are no adequate and well-controlled studies in pregnant women. Entecavir should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

Use in lactation: It is not known whether Entecavir is excreted in human milk. Mothers should be instructed not to breast-feed if they are taking Entecavir.

Precautions & Warnings

Monitor liver function tests every 3 months, and viral and serological markers for hepatitis B every 3-6 months. Discontinue if deterioration in liver function, hepatic steatosis, progressive hepatomegaly or unexplained lactic acidosis. Recurrent hepatitis may occur on discontinuation.

Use in Special Populations

Use in pediatric patient: Safety and effectiveness of Entecavir in pediatric patients below the age of 16 years have not been established.

Use in geriatric patient: Entecavir is significantly excreted by the kidney, and the risk of toxic reactions to this drug may be greater in patients with impaired renal function. Because elderly patients are more likely to have decreased renal function, care should be taken in dose selection, and it may be useful to monitor renal function.

Dose adjustment in renal impairment: Dose adjustment is recommended for patients with CrCl <50 ml/min including patients on hemodialysis or continuous ambulatory peritoneal dialysis (CAPD) as shown in the following table.

CrCl ≥50 ml/min: 0.5 mg every 24 hours
CrCl 30 to <50 ml/min: 0.5 mg every 48 hours
CrCl 10 to <30 ml/min: 0.5 mg every 72 hours
CrCl <10 ml/min or  Hemodialysis or CAPD: 0.5 mg every 7 days

Overdose Effects

There is no experience of Entecavir overdosage reported in patients. Healthy subjects who received up to 20 mg daily for up to 14 days and single doses up to 40 mg had no unexpected adverse events. If overdosage occurs, the patient must be monitored for evidence of toxicity and standard supportive treatment as necessary.

Storage Conditions

Store at temperatures not above 30°C.

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VIR - 0.50 mg Tablet/pcs

৳  48.14

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